Dr. Nirmal Singh

MassBay Title

Chair of the Biotechnology Department
Founding Director, The Center for Therapeutics and Genomics Training

Education

B.Sc., Chemistry, Botany, Zoology, TM Bhagalpur University.

M.Sc., Cytogenetics and Plant Breeding, TM Bhagalpur University,

Ph.D., Botany (Plant Tissue Culture/Biotechnology), University of Delhi.

Post-Doctoral Training, University of Delhi South Campus, Delhi, Univ. of Massachusetts Medical School, Texas A & M University, and Scott & White Hospital.

Professional Accomplishments

Dr. Singh has taught several undergraduate courses, reviewed scientific journals, written and managed grants, managed laboratory personnel, published and presented research papers, patented research findings, authored book chapters, served as a scientific advisor, and most importantly developed novel and internationally acclaimed therapeutic candidates for the treatment of the neurological disease, SMA.

U.S. Patent

Singh N. K., et al., “Spinal Muscular Atrophy (SMA) Treatment via targeting of SMN2 Splice Site Inhibitory Sequences” (United States Patent Application 20070292408).

Publications

• Li, H. J., Ray, S. K., Singh, N. K., Johnston, B., and A. B. (2011) Basic helix loop helix transcription factors, and enteroendocrine cell differentiation. Diabetes, Obesity, and Metabolism. 13 (Suppli 1) 5-12.
• Nirmal K. Singh, PREETHI RAO AND ALEXZANDER ASEA (2008) “Silencing of Metastasis-associated Gene 1 (Mta1) Stimulates Hsp70 Cellular Release and Neurite extension in Neuroblastoma Cells.” Chapter 14. IN Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection. Springer, Volume 3, pp. 273 – 282. BOOK CHAPTER.
• Nirmal K. Singh, Natalia N. Singh, Elliot J. Androphy, and Ravindra N. Singh (2006) Splicing of a critical exon of human survival motor neuron is regulated by unique silencer element located in the last intron. Mol Cell Biol 26: 1333-1346.
• Nirmal K. Singh and C.B.Sehgal (1999) Micro propagation of “Holy Basil” (Ocimum sanctum Linn.) from young inflorescences of mature plants. Plant Growth Regulation 29: 161-166.
• D. Jani, N. K. Singh, S. Bhattacharyya, L.S. Meena, M. Thungapathra, J.K. Gautam, A. Ghosh, S. N. Upadhyay, Y. Singh, A. K. Sharma and A. K. Tyagi (2004) Studies on Immunogenic Potential of Plant Expressed Cholera toxin B Subunit. Plant Cell Rep 22: 471- 477.
• Manoj Kumar Sharma, Nirmal Kumar Singh, Dewal Jani, Rama Sisodia, M. Thungapathra, J. K. Gautam, L.
• S. Meena, Yogendra Singh, Amit Ghosh, Akhilesh Kumar Tyagi, Arun Kumar Sharma (2008) Expression of Toxin co-regulated pilus subunit A (TCPA) of Vibrio cholerae and its immunogenic epitopes fused to cholera toxin B subunit in transgenic tomato (Solanum lycopersicum). Plant Cell Rep 27: 307- 318.